“ beyond the expected general anti-inflammatory properties that UA has, it may also allow for greater immunomodulation wherein the body can detect and manage early tumor growths in the gastrointestinal tract, like those seen in colorectal cancer,” noted Dr. They thus wrote that UA’s positive effects are dependent on the presence of certain T cells. In the end, they found that mice on UA diets experienced a significant decrease in tumor incidence and size, alongside a higher level of T cells in the inner lining of the colon.įrom further experiments, they found that UA’s positive immune effects were neither present in mice without mature T and B cells, nor those depleted of CD8+ T cells. We hope to use this to sustainably improve the therapy of colorectal cancer, but also of other cancers,” he added.įor the study, the researchers gave mouse models of colorectal cancer a UA-containing diet or control diet for 18 weeks. By possibly improving the combination therapy with existing immunotherapies, the study opens up meaningful possibilities for further application in the clinic. “This is where reliable therapeutic approaches are still lacking in the reality of colorectal cancer patients. Dominic Denk, physician at Frankfurt University Hospital, in Germany, and first author of the current study. “Our findings are particularly exciting because the focus is not on the tumor cell but on the immune system, the natural defense against cancer,” said Dr. They found that UA induced “strongly protective” anti-tumor T cell immunity in mice both when consumed in food and when used alongside CAR-T cell therapy, a treatment in which T cells - a type of immune cell - are altered to attack cancer cells. Recently, researchers explored the effects of UA on colorectal cancer in mice. Other studies have found that UA has immunomodulatory effects in cells that reduce inflammation alongside cells that enhance immune function.įurther study of the effects of UA on immune function could lead to the development of anti-tumor treatments. In turn, this encourages the creation of new mitochondria and slows the progression of age-related diseases. Recent studies show that concentrated forms of urolithin A (UA), a natural product of pomegranate digestion, induce mitophagy - the breakdown of old or redundant “cellular powerhouses” known as mitochondria. A patient’s chances of survival can be predicted by their immunoscore, which is calculated from the density of cell-death-inducing cells (CD8+ cells) inside tumors.
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